Prevalence of obstructive sleep apnea in patients who have started empirical therapy with CPAP during their hospitalization for SARS COV-2

Authors

  • VERÓNICA LÓPEZ GARCÍA Enfermera. Unidad Multidisciplinar de Sueño y Ventilación J. Terán Santos. Hospital Universitario de Burgos
  • ESTEFANIA RIVAS NAVAS Médico especialista en Neurofisiología. Unidad Multidisciplinar de Sueño y Ventilación Dr. J. Terán Santos. Dirección postal: Hospital Universitario de Burgos. 1ª planta, bloque E. Avd. Islas Baleares 3. 09006. Burgos.
  • CARMEN MUÑOZ PELÁEZ Licenciada en Biología. Fundación Burgos por la investigación de la salud. Dirección postal: Hospital Universitario de Burgos. 1ª planta, bloque e. Avd. Islas Baleares 3. 09006. Burgos.
  • ROCÍO SANZ MERINO Enfermera. Unidad Multidisciplinar de Sueño y Ventilación Dr. J. Terán Santos. Dirección postal: Hospital Universitario de Burgos. 1ª planta, bloque e. Avd. Islas Baleares 3. 09006. Burgos.

DOI:

https://doi.org/10.60108/ce.282

Keywords:

Sleep Apnea, Obstructive, COVID-19, SARS- CoV-2, Respiratory Distress Syndrome, Adult, CPAP, Polysomnography

Abstract

During the SARS Cov-2 pandemic, the use of CPAP became widespread. Medical societies recommend its use in patients with acute respiratory failure secondary to infection as it has been proven to reduce the need for invasive mechanical ventilation and prevent or delay admission to the ICU. In some patients, empiric treatment with CPAP was initiated during their admission due to suspected undiagnosed obstructive sleep apnea, and treatment was continued at home.

The objective of this study was to determine the prevalence of OSA in patients who initiated empirical CPAP therapy for suspected OSA during their hospitalization for ARDS secondary to SARS CoV-2.

Methodology: This is a prospective, observational and analytical study.

A sleep study, baseline polysomnography, was performed on patients who started empirical therapy with CPAP due to symptoms suggestive of OSA during their admission with SARS CoV-2 ARDS between March 2020 and December 2021 and who continued with the treatment at home without a diagnostic test.

Results: Of the 348 patients who required ventilatory support, 43 patients had a previous diagnosis of OSA (12.35%). Of the 14 patients recruited, the diagnosis of OSA was confirmed in 85.7% of the cases after the sleep study, with a mean AHI in patients with ICU admission of 54.4/h and without ICU admission of 32.2/h.

Conclusion: There is a tendency that the severity of OSA is associated with a worse evolution of SARS CoV-2 disease.

Author Biographies

  • ESTEFANIA RIVAS NAVAS, Médico especialista en Neurofisiología. Unidad Multidisciplinar de Sueño y Ventilación Dr. J. Terán Santos. Dirección postal: Hospital Universitario de Burgos. 1ª planta, bloque E. Avd. Islas Baleares 3. 09006. Burgos.

    Licenciada en Medicina. Médico especialista en Neurofisiología.

  • CARMEN MUÑOZ PELÁEZ, Licenciada en Biología. Fundación Burgos por la investigación de la salud. Dirección postal: Hospital Universitario de Burgos. 1ª planta, bloque e. Avd. Islas Baleares 3. 09006. Burgos.

    Licenciada en Biología.

  • ROCÍO SANZ MERINO, Enfermera. Unidad Multidisciplinar de Sueño y Ventilación Dr. J. Terán Santos. Dirección postal: Hospital Universitario de Burgos. 1ª planta, bloque e. Avd. Islas Baleares 3. 09006. Burgos.

    Diplomada en Enfermería. 

References

Gorbalenya, A. E.; Baker, S. C.; Baric, R. S.; de Groot, R. J.; Drosten, C.; Gulyaeva, A. A.; Haagmans, B. L.; Lauber, C.; Leontovich, A. M.; Neuman, B. M.; Penzar, D.; Poon, L. L. M.; Samborskiy, D.; Sidorov, I. A.; Sola, I.; Ziebuhr, J. «Severe acute respiratory syndrome-related coronavirus: The species and its viruses - a statement of the Coronavirus Study Group». bioRxiv

Chaolin Huang; Yeming Wang; Xingwang Li; Lili Ren; Jianping Zhao; Yi Hu; Li Zhang; Guohui Fan; Jiuyang Xu; Xiaoying Gu. «Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China» [Características clínicas de los pacientes infectados con la nueva enfermedad de coronavirus de 2019 en Wuhan, China]. The Lancet. p. 3.

WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard With Vaccination Data

Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis 2020; 94:91e5.

L’Her E, Taille S, Deye N, Lellouche F, Fraticelli A, Demoule A, et al. Physiological response of hypoxemic patients to different modes of noninvasive ventilation.Am J Respir Crit Care Med. 2003;168:27.

Masip J, Roque M, Sánchez B, Fernández R, Subirana M, Expósito JA. Noninvasive ventilation in acute cardiogenic pulmonary edemasystematic review and metaanalysis. JAMA. 2005; 294:3124–30.

Alhazzani W, Møller MH, Arabi YM, Loeb 3M, Gong MN, Fan E, et al. Surviving sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19). Crit Care Med. 2020, https://goo.su/Miqw

Cinesi-Gómez C, Carratalá-Perales JM. Soporte respiratorio en el paciente adulto con insuficiencia respiratoria aguda secundaria a COVID-19 en urgencias y emergencias. Emergencias. 2020; 32:197–200.

Pinto JA, Ribeiro DK, da Silva Cavallini AF, Duarte C, Freitas GS. Comorbidities associated with obstructive sleep apnea: a retrospective study. Int Arch Otorhinolaryngol 2016; 20(2):145e50.

Miller MA, Cappuccio FP. A systematic review of COVID-19 and obstructive sleep apnoea. Sleep Med Rev. 2021 Feb; 55:101382. doi: 10.1016/j.smrv.2020.101382. Epub 2020 Sep 8. PMID: 32980614; PMCID: PMC7833740.

McSharry D, Lam MT, Malhotra A. OSA as a probable risk factor for severe COVID-19. J Clin Sleep Med 2020 Sep 15; 16(9):1649. 1649.

Perkins GD, Ji C, Connolly BA, et al. Fuente: medRxiv 2021 [preprint]. An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19

Bellani G, Patroniti N, Greco M, Foti G, Pesenti A. The use of helmets to deliver non-invasive continuous positive airway pressure in hypoxemic acute respiratory failure. Minerva Anestesiol. 2008; 74:651–6.

Saxena K, Kar A, Goyal A. COVID 19 and OSA: exploring multiple cross-ways. Sleep Med 2021 Mar; 79:223.

Suquia AG, Alonso-Fernandez A, De La Pe~na M, et al. High D-dimer levels after stopping anticoagulants in pulmonary embolism with sleep apnoea. Eur Respir J 2009; 46(820):1691e700.

Stefan N., Birkenfeld A.L., Schulze M.B., Ludwig D.S. Obesity and impaired metabolic health in patients with COVID-19. Nat Rev Endocrin. 2020 doi: 10.1038/s41574-020-0364-6.

Simonnet A., Chetboun M., Poissy J., Reverdy V., Noulette J., Duhamel A. High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity. 2020 doi: 10.1002/oby.22831.

Petrilli C.M., Jones S.A., Yang J., Rajagopalan H., O’Donnell L.F., Chernyak Y. Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York city. medRxiv. 2020 doi: 10.1101/2020.04.08.20057794.

Lighter J., Phillips M., Hochman S., Sterling S., Johnson D., Francois F. Obesity in patients younger than 60 years is a risk factor for covid-19 hospital admission. Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa415.

Caussy C., Wallet F., Laville M., Disse E. Obesity is associated with severe forms of COVID-19. Obesity. 2020 doi: 10.1002/oby.22842.

Carmen Pérez-Rodrigo, Gotzone Hervás Bárbara, Marta Gianzo Citores, Javier Aranceta-Bartrina. Prevalence of obesity and associated cardiovascular risk factors in the Spanish population: the ENPE study. 28 de enero de 2021.

Iannelli A, Favre G, Frey S, et al. Obesity and COVID 19: ACE 2, the missing tile.

Terán-Santos J, Egea Santaolalla C, Montserrat JM, et al.: Sleep Apnea and Driving. Recommendations for Interpreting Spanish Regulations for Drivers. Arch Bronconeumol. 2017; 53(6):336–41. 10.1016/j.arbres.2016.11.007

Manuel Sánchez-de-la-Torre, PhD, Francisco Campos-Rodriguez, MD, Prof Ferran Barbé, MD Obstructive sleep apnoea and cardiovascular disease, The Lancet Respiratoy Medicine, volumen 1, ISSUE 1, P61-72, MARCH 01, 2013, DOI:https://doi.org/10.1016/S2213-2600(12)70051-6

O. Mediano, N. Gonzalez Mangado, J.M. Montserrat et al., Documento internacional de consenso sobre apnea obstructiva del sueño, Archivos de Bronconeumologia, https://doi.org/10.1016/j.arbres.2021.03.017

Sanchez Quiroga MA, Corral J, Gomez de Terreros FJ, Carmona Bernal C, Asensio Cruz MI, Cabello M, et al. Primary care physicians can comprehensively manage patients with sleep apnea. Am J Respir Crit Care Med. 2018;198:648–56,http://dx.doi.org/10.1164/rccm.201710-2061OC.

Tarraubella N, Sanchez-de-la-Torre M, Nadal N, de Batlle J, Benitez I, Cortijo A, et al. Management of obstructive sleep apnoea in a primary care vs sleep unit setting: A randomised controlled trial. Thorax. 2018;73:1152–60, http://dx.doi.org/10.1136/thoraxjnl-2017-211237

Weaver TE, Mancini C, Maislin G, Cater J, Staley B, Landis JR, et al. Continuous positive airway pressure treatment of sleepy patients with milder obstructive sleep apnea: Results of the CPAP Apnea Trial North American Program (CATNAP) randomized clinical trial. Am J Respir Crit Care Med. 2012; 186:677–83.

Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG. Treatment of adult obstructive sleep apnea with positive airway pressure: An American Academy of Sleep Medicine Systematic review, a meta-analysis, and GRADE assessment. J Clin Sleep Med. 2019; 15:301–34.

Patil SP, Shirsath LP, Chaudhari BL. Treatment of adult obstructive sleep apnea with positive airway pressure: An American Academy Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2019;15:335.

Additional Files

Published

2024-10-29

How to Cite

Prevalence of obstructive sleep apnea in patients who have started empirical therapy with CPAP during their hospitalization for SARS COV-2. (2024). Conocimiento Enfermero, 7(26), 60-67. https://doi.org/10.60108/ce.282